Many of our products can be used in Suzuki-Miyaura cross-coupling reaction such as 4-Bromotoluene. But what is this cross-coupling reaction and where is it used? This article will elaborate on the details of this cross-coupling reaction.
The Suzuki coupling reaction is an organic reaction catalyzed by palladium to cross-couple a boronic acid to an organohalide. This reaction is related to the Miyaura borylation and combined, it is called the Suzuki-Miyaura reaction.
The main components in a Suzuki-Miyaura cross-coupling reaction are organoboronic acid or ester, organic halide or triflate, and palladium catalyst. The organoboronic acid or ester provides the carbon to be coupled. Organic halide or triflate provides the other carbon fragment and the halide or triflate leaving group. Palladium is the catalyst facilitating the reaction speed.
The reaction typically takes place under mild conditions with room temperature or slightly higher temperature. The Suzuki-Miyaura reaction is widely used in many pharmaceutical synthesis, including those for cardiovascular diseases (e.g. valsartan and losartan) and cancer treatment (e.g. lapatinib).